Narrative Review

Dental-dedicated magnetic resonance imaging for

pulpal and periapical diagnosis compared with cone beam computed tomography

Farnaz Namazi 1

Reese K. Williams 2

Vyas Yesha 2

Domenico Ricucci 3

Franklin Tay 4

https://doi.org/10.71347/cgrt75d8


1 Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Georgia, USA

2 Dental College of Georgia, Augusta University, USA

3 Private practice, Cetraro, Italy

4 Department of Endodontics, Dental College of Georgia, Augusta University, Augusta, GA, USA


Corresponding author:

Franklin Tay, Dental College of Georgia, Augusta University, Augusta, GA, USA.

Email: ftay@augusta.edu

Key words: apical periodontitis; cone beam computed tomography; dental-dedicated magnetic resonance

imaging; endodontics; periapical diagnosis

Acknowledgements: The authors deny any conflicts of interest. They thank Marie Churchville for secretarial support.

Cite this article

Abstract


Introduction: Periapical diagnosis in endodontics depends largely on radiographic evidence of mineralized tissue changes. Cone beam computed tomography (CBCT) improves three-dimensional assessment of periapical bone loss, root anatomy, and surgical planning. However, it does not directly depict pulpal status or soft tissue inflammatory changes. This narrative review examined dental-dedicated magnetic resonance imaging (ddMRI) for periapical diagnosis compared with CBCT, with emphasis on the transition from historical dental MRI to a dedicated dental platform.

Methods: The review distinguished pre-2024 dental MRI studies performed on conventional medical MRI systems from ddMRI studies based on the low-field, coil-specific, task-oriented platform introduced by Greiser et al. in 2024. Evidence was synthesized around lesion detection, inflammatory change, lesion characterization, artifacts, radiation exposure, workflow, and clinical positioning.

Results: Dental MRI showed that MRI could detect periapical lesions, depict fluid-rich and marrow-related changes, and characterize cystic versus granulomatous lesions. Dental-dedicated MRI extends this work through localized acquisition, dedicated hardware, and task-specific sequences. Early ddMRI evidence suggests potential for evaluating pulp vitality, regeneration and periapical edema-like change within one non-ionizing examination. However, current data are limited by small feasibility studies and incomplete validation.

references

American Association of Endodontists, American Academy of Oral and Maxillofacial Radiology (2016). Use of cone beam computed tomography in endodontics: 2015/2016 update. AAE/AAOMR joint position statement [Internet]. Chicago: American Association of Endodontists [accessed Apr 26, 2026]. Available from: https://www.aae.org

Astary GW, Peprah MK, Fisher CR, Stewart RL, Carney PR, Sarntinoranont M, Meisel MW, Manuel MV, Mareci TH (2013). MR measurement of alloy magnetic susceptibility: towards developing tissue-susceptibility matched metals. J Magn Reson 233, 49-55. https://doi.org/10.1016/j.jmr.2013.05.002

Bender IB (1982). Factors influencing the radiographic appearance of bony lesions. J Endod 8, 161-170. https://doi.org/10.1016/S0099-2399(82)80212-4

Berger A (2002). Magnetic resonance imaging. BMJ 324, 35. https://doi.org/10.1136/bmj.324.7328.35

Bohner L, Hanisch M, Sesma N, Blanck-Lubarsch M, Kleinheinz J (2022). Artifacts in magnetic resonance imaging caused by dental materials: a systematic review. Dentomaxillofac Radiol 51, 20210450. https://doi.org/10.1259/dmfr.20210450

Chogle S, Zuaitar M, Sarkis R, Saadoun M, Mecham A, Zhao Y (2020). The recommendation of cone-beam computed tomography and its effect on endodontic diagnosis and treatment planning. J Endod 46, 162-168. https://doi.org/10.1016/j.joen.2019.10.034

Coşkun Albayrak S, Özdemir ÖS (2025). Awareness of Cone Beam Computed Tomography (CBCT) use and radiation safety among dentists and specialists. BMC Oral Health 25, 1436. https://doi.org/10.1186/s12903-025-06754-0

Dentsply Sirona, Siemens Healthineers (2024). The journey to dental-dedicated magnetic resonance imaging [Internet]. Dentsply Sirona [accessed Apr 24, 2026]. Available from: https://www.dentsplysirona.com/content/dam/master/product-procedure-brand-categories/imaging/product-categories/ddmri/IMG-White-paper-ddMRI-2025.pdf.coredownload.pdf

Fontenele RC, Nascimento EHL, Gaêta-Araujo H, Cardelli LOA, Freitas DQ (2021). Which factors related to apical radiolucency may influence its radiographic detection? A study using CBCT as reference standard. Restor Dent Endod 46, e43. https://doi.org/10.5395/rde.2021.46.e43

Flügge T, Gross C, Ludwig U, Schmitz J, Nahles S, Heiland M, Nelson K (2023). Dental MRI: only a future vision or standard of care? A literature review on current indications and applications of MRI in dentistry. Dentomaxillofac Radiol 52, 20220333. https://doi.org/10.1259/dmfr.20220333

Flügge T, Hövener JB, Ludwig U, Eisenbeiss AK, Spittau B, Hennig J, Schmelzeisen R, Nelson K (2016). Magnetic resonance imaging of intraoral hard and soft tissues using an intraoral coil and FLASH sequences. Eur Radiol 26, 4616-4623. https://doi.org/10.1007/s00330-016-4254-1

Geibel MA, Schreiber ES, Bracher AK, Hell E, Ulrici J, Sailer LK, Ozpeynirci Y, Rasche V (2015). Assessment of apical periodontitis by MRI: a feasibility study. Rofo 187, 269-275. https://doi.org/10.1055/s-0034-1385808

Geibel MA, Schreiber E, Bracher AK, Hell E, Ulrici J, Sailer LK, Rasche V (2017). Characterisation of apical bone lesions: Comparison of MRI and CBCT with histological findings - a case series. Eur J Oral Implantol 10, 197-211.

Greiser A, Christensen J, Fuglsig JMCS, Johannsen KM, Nixdorf DR, Burzan K, Lauer L, Krueger G, Hayes C, Kettless K, Ulrici J, Spin-Neto R (2024). Dental-dedicated MRI, a novel approach for dentomaxillofacial diagnostic imaging: technical specifications and feasibility. Dentomaxillofac Radiol 53, 74-85. https://doi.org/10.1093/dmfr/twad004

Han B, Chen N, Luo J, Afkhami F, Peters OA, Wang X (2025). Magnetic Resonance Imaging for Dental Pulp Assessment: A Comprehensive Review. J Magn Reson Imaging 62, 362-388. https://doi.org/10.1002/jmri.29742

Huang C, Chen G, Lu B, Sun X (2026). The Application of Magnetic Resonance Imaging in Dentistry: A Bibliometric Analysis. Int Dent J 76, 104010.  https://doi.org/10.1016/j.identj.2025.104010

Huumonen S, Ørstavik D (2002). Radiological aspects of apical periodontitis. Endod Topics 1, 3-25. https://doi.org/10.1034/j.1601-1546.2002.10102.x

Imai H, Tanaka Y, Nomura N, Tsutsumi Y, Doi H, Kanno Z, Ohno K, Ono T, Hanawa T (2013). Three-dimensional quantification of susceptibility artifacts from various metals in magnetic resonance images. Acta Biomater 9, 8433-8439. https://doi.org/10.1016/j.actbio.2013.05.017

Johannsen K, Christensen J, Kirkevang LL, Matzen LH, Spin-Neto R (2026). Dental-Dedicated MRI in the Assessment of Pulp Vitality and Apical Periodontitis: A Feasibility Study. Int Endod J 59, 776-787. https://doi.org/10.1111/iej.70101

Johannsen KM, Christensen J, Matzen LH, Hansen B, Spin-Neto R (2025). Interference of titanium and zirconia implants on dental-dedicated MR image quality: ex vivo and in vivo assessment. Dentomaxillofac Radiol 54, 132-139. https://doi.org/10.1093/dmfr/twae071

Juerchott A, Pfefferle T, Flechtenmacher C, Mente J, Bendszus M, Heiland S, Hilgenfeld T (2018). Differentiation of periapical granulomas and cysts by using dental MRI: a pilot study. Int J Oral Sci 10, 17. https://doi.org/10.1038/s41368-018-0017-y

Kalogeropoulos K, Xiropotamou A, Koletsi D, Tzanetakis GN (2022). The effect of cone-beam computed tomography evaluation on treatment planning after endodontic instrument fracture. Int J Environ Res Public Health 19, 4088. https://doi.org/10.3390/ijerph19074088

Kress B, Buhl Y, Anders L, Stippich C, Palm F, Bähren W, Sartor K (2004). Quantitative analysis of MRI signal intensity as a tool for evaluating tooth pulp vitality. Dentomaxillofac Radiol 33, 241-244. https://doi.org/10.1259/dmfr/33063878  

Kruse C, Spin-Neto R, Evar Kraft DC, Vaeth M, Kirkevang LL (2019). Diagnostic accuracy of cone beam computed tomography used for assessment of apical periodontitis: an ex vivo histopathological study on human cadavers. Int Endod J 52, 439-450. https://doi.org/10.1111/iej.13020

Lizio G, Salizzoni E, Coe M, Gatto MR, Asioli S, Balbi T, Pelliccioni GA (2018). Differential diagnosis between a granuloma and radicular cyst: effectiveness of magnetic resonance imaging. Int Endod J 51, 1077-1087. https://doi.org/10.1111/iej.12933

Maraghelli D, Brandi ML, Matucci Cerinic M, Peired AJ, Colagrande S (2021). Edema-like marrow signal intensity: a narrative review with a pictorial essay. Skeletal Radiol 50, 645-663. https://doi.org/10.1007/s00256-020-03632-4

Niraj LK, Patthi B, Singla A, Gupta R, Ali I, Dhama K, Kumar JK, Prasad M (2016). MRI in dentistry: A future towards radiation free imaging - systematic review. J Clin Diagn Res 10, ZE14-ZE19. https://doi.org/10.7860/JCDR/2016/19435.8658

Öcbe M (2025). The evolving role of MRI in dentomaxillofacial diagnostics: a comprehensive review. Eur Oral Res 59, 58-67. https://doi.org/10.26650/eor.2024145664

Park CS, Kang SR, Kim JE, Huh KH, Lee SS, Heo MS, Han JJ, Yi WJ (2023). Validation of bone mineral density measurement using quantitative CBCT image based on deep learning. Sci Rep 13, 11921. https://doi.org/10.1038/s41598-023-38943-8

Patel S, Wilson R, Dawood A, Foschi F, Mannocci F (2012). The detection of periapical pathosis using digital periapical radiography and cone beam computed tomography - part 2: a 1-year post-treatment follow-up. Int Endod J 45, 711-723. https://doi.org/10.1111/j.1365-2591.2012.02076.x 

Pigg M, List T, Abul-Kasim K, Maly P (2014). A comparative analysis of magnetic resonance imaging and radiographic examinations of patients with atypical odontalgia. J Oral Facial Pain Headache 28, 233-242. https://doi.org/10.11607/ofph.1230

Reda R, Zanza A, Mazzoni A, Cicconetti A, Testarelli L, Di Nardo D (2021). An Update of the Possible Applications of Magnetic Resonance Imaging (MRI) in Dentistry: A Literature Review. J Imaging 7:75. https://doi.org/10.3390/jimaging7050075

Remick KA, Helmann JD (2023). The elements of life: A biocentric tour of the periodic table. Adv Microb Physiol 82, 1-127. https://doi.org/10.1016/bs.ampbs.2022.11.001

Schulze R, Heil U, Gross D, Bruellmann DD, Dranischnikow E, Schwanecke U, Schoemer E (2011). Artefacts in CBCT: a review. Dentomaxillofac Radiol 40, 265-273. https://doi.org/10.1259/dmfr/30642039

Tay KX, Lim LZ, Goh BKC, Yu VSH (2022). Influence of cone beam computed tomography on endodontic treatment planning: A systematic review. J Dent 127, 104353. https://doi.org/10.1016/j.jdent.2022.104353

Vaddi A, Parasher P, Khurana S (2025). Beyond X-Rays: Unveiling the Future of Dental Diagnosis with Dental Magnetic Resonance Imaging. Diagnostics (Basel) 15, 1153. https://doi.org/10.3390/diagnostics15091153

Venskutonis T, Plotino G, Juodzbalys G, Mickevičienė L (2014). The importance of cone-beam computed tomography in the management of endodontic problems: a review of the literature. J Endod 40, 1895-1901. https://doi.org/10.1016/j.joen.2014.05.009

Wong J, Zhang C, Lee AHC (2025). Clinical Benefits and Limitations of Cone-Beam Computed Tomography in Endodontic Practice: A Contemporary Evidence-Based Review. Diagnostics (Basel). 15, 3117. https://doi.org/10.3390/diagnostics15243117